Notice: Function _load_textdomain_just_in_time was called incorrectly. Translation loading for the wordpress-seo domain was triggered too early. This is usually an indicator for some code in the plugin or theme running too early. Translations should be loaded at the init action or later. Please see Debugging in WordPress for more information. (This message was added in version 6.7.0.) in /var/www/html/wp-includes/functions.php on line 6260 Genistein - Nutraceuticals World

What are you searching for?

Sign in
Research

Genistein

Author Image

By: Sean Moloughney

Editor, Nutraceuticals World

Indication: Bone density


Source: Ann Intern Med, June 19, 2007;146(12):839-47.

Research: To assess the effects of genistein on bone metabolism in nearly 400 osteopenic postmenopausal women, researchers conducted a randomized, double-blind, placebo-controlled trial. Women in the study had a bone mineral density (BMD) less than 0.795 g/cm2 at the femoral neck and no significant comorbid conditions. After a 4-week stabilization period during which participants received a low-soy, reduced-fat diet, participants were randomly assigned to receive placebo (n = 191) or 54 mg of genistein (n = 198) daily for 24 months. Both the genistein and placebo tablets contained calcium and vitamin D.

Results: At 24 months, BMD had in-creased in genistein recipients and decreased in placebo recipients at the anteroposterior lumbar spine and the femoral neck. Genistein also statistically significantly decreased urinary excretion of pyridinoline and deoxypyridinoline, increased levels of bone-specific alkaline phosphatase and insulin-like growth factor I, and did not change endometrial thickness compared with placebo. However, more genistein recipients than placebo recipients experienced gastrointestinal side effects and discontinued the study. As far as limitations, the study did not measure fractures and had limited power to evaluate adverse effects. This, however, did not stop researchers from concluding that 24 months of treatment with genistein may have positive effects on BMD in osteo-penic postmenopausal women.

Add us as a preferred source on Google

Get the latest Nutraceuticals World news, insights and analysis in your Google Search and AI experiences.

Add Nutraceuticals World as a preferred source on Google (opens in a new tab)

Keep Up With Our Content. Subscribe To Nutraceuticals World Newsletters